Endocrine Abstracts

Maternal nutrient restriction has been suggested to influence adult offspring HPA axis function. Here, we have studied maternal global nutrient or specific protein restriction and characterised offspring HPA axis response (of plasma cortisol and metabolite excursions) to an insulin tolerance test at 1 year of age. Thirty-nine pregnant sheep were either fed a control diet (replete in energy and protein; n=12) meeting maintenance energy requirements 1.0 M or were fed a di...

The intraperitoneal environment of the ovarian surface epithelium (OSE) has an oxygen (O2) tension of 5–12%. This could impact cellular events leading to ovulation. Furthermore, ovarian cancers arising from the OSE (∼80–90% of ovarian malignancies) are likely to experience increased hypoxia due to the relatively poor vascularisation of solid tumours.Using 1%, 5% or 20% O2, we measured the expression of HSD11B1, COX-2...